AMC Current Studies
| NCT Number | Status | |
|---|---|---|
| AMC-105 - A Multicenter, Open-label Feasibility Study of Daratumumab with Dose-Adjusted EPOCH in Newly Diagnosed Plasmablastic Lymphoma | NCT04139304 | Actively enrolling |
| AMC-112 - Axicabtagene Ciloleucel in Relapsed or Refractory HIV-Associated Aggressive B-Cell Non-Hodgkin Lymphoma | NCT05077527 | Actively enrolling |
| AMC-120 - A Feasibility Study of Glofitamab plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma | TBD | In Development |
| AMC-119 - Epcoritamab in Combination with Dose Adjusted EPOCH-R for High-risk Burkitt Lymphoma (BL) (BEDROCK Study) | TBD | In Development |
| AMC-044 - Phase II Trial Of ESHAP (Etoposide, Methylprednisolone, Cytosine Arabinoside, And Cisplatin) Followed By Zevalin As Consolidation Therapy In Relapsed/Refractory AIDS-Related Lymphomas | NCT00310128 | Closed to accrual |
| AMC-053 - Safety And Efficacy Trial Of The Anti-Viral And Anti-Tumor Activity Of Velcade Combined With (R) ICE In Subjects With Relapsed/Refractory AIDS-Associated Lymphoma | NCT00598169 | Closed to accrual |
| AMC-113 - Observational Cohort Study of People Living with HIV Treated with CD19-Directed CAR T Cell Therapy for B-Cell Lymphoid Malignancies | NCT05784415 | Closed to accrual |
| AMC-068 - Randomized, Phase II Trial of CHOP vs. Oral Chemotherapy with Concomitant Antiretroviral Therapy in Patients with HIV-associated Lymphoma in Sub-Saharan Africa | NCT01775475 | Closed to accrual |
| AMC-071/BMT CTN 0803 - High Dose Chemotherapy with Autologous Stem Cell Rescue for Aggressive B Cell Lymphoma and Hodgkin Lymphoma in HIV-infected Patients | NCT01141712 | Closed to accrual |
| AMC-109 - Administration of HIV-specific T cells to HIV+ Patients Receiving High Dose Chemotherapy Followed by Autologous Stem Cell Rescue -Auto-RESIST | NCT04975698 | Closed to accrual |
| AMC-073 - Phase II Study of Response-Adapted Therapy Using Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy Comprising ABVD With Versus Without Combination Chemotherapy Comprising Standard or Escalated BEACOPP in Patients with Stage III-IV Hodgkin Lymphoma | NCT01319526 | Closed to accrual |
| AMC-075 - A Sequential Phase I/Randomized Phase II Trial of Vorinostat and Risk-Adapted Chemotherapy with Rituximab in HIV-Related B-cell Non-Hodgkin’s Lymphoma | NCT01193842 | Closed to accrual |
| AMC-079 - Quantification of HIV-1 Reservoirs in HIV-Positive Persons Receiving Response-Adapted Therapy for Stage III-IV Hodgkin Lymphoma: A Companion Protocol to SWOG Protocol S0816 (AMC-073) | NCT01319526 | Closed to accrual |
| AMC-080/BMT CTN 0903 - Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodysplastic Syndromes in HIV-Infected Individuals | NCT01410344 | Closed to accrual |
| AMC-097 - A Phase I Study of Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-Selected CD34+ Cells | NCT02797470 | Closed to accrual |
| AMC-101 - Phase I and Dose-Expansion Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas | NCT03220022 | Closed to accrual |
| AMC-085 - A Phase 1/2 Study Examining AVD and Brentuximab Vedotin in Patients with HIV and Advanced Stage Hodgkin's Lymphoma | NCT02298257 | Closed to accrual |
| AMC-086/9177 - Phase II Study of Dose-Adjusted EPOCH+/- Rituximab in Adults with Untreated Burkitt Lymphoma, C-Myc Positive Diffuse Large B-Cell Lymphoma and Plasmablastic Lymphoma | Closed to accrual | |
| AMC-091 - Phase I and Pharmacokinetic Study of Ibrutinib in HIV-Infected Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma | NCT02109224 | Closed to accrual |
| NCT Number | Status | |
|---|---|---|
| AMC-103 - A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive Individuals | NCT03603808 | Closed to accrual |
| AMC-A01 - Anal Cancer/HSIL Outcomes Research (ANCHOR) Study | NCT02135419 | Closed to accrual |
| AMC-099 - HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV (COVENANT) | NCT03284866 | Closed to accrual |
| AMC-092 - A multicenter observational and feasibility study of excision of superficially invasive squamous cell carcinoma (SISCCA) of the anal canal and perianus in HIV-infected persons | NCT02437851 | Closed to accrual |
| AMC-093 - Incidence of HIV and Other STI Among Indian Men Who Have Sex with Men (MSM) | NCT04142385 | Closed to accrual |
| AMC-094 - HPV-Related Neoplasia Among HIV-Seropositive Indian Men Who Have Sex with Men (MSM) | NCT04142398 | Closed to accrual |
| AMC-102 - Phase IIB Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Paclitaxel and Carboplatin in HIV-Infected Women with Locally Advanced Cervical Cancer (LACC) | NCT03834571 | Closed to accrual |
| AMC-088 - A Randomized Phase III Study of Intra-anal Imiquimod 2.5% vs. Topical 5-Fluorouracil 5% vs. Observation for the Treatment of High-grade Squamous Anal Intraepithelial Lesions (HSIL) in HIV-infected Men and Women | NCT02059499 | Closed to accrual |
| AMC-S006 - Improving Participation in AMC Clinical Trials (IMPACTS) | NCT01946217 | Closed to accrual |
| AMC-S008 - Prospective Observational Study of Site-Specific Incident and Prevalent Cases of Cancer in People Living with HIV/AIDS- in Latin America | NCT04089488 | Closed to accrual |
| AMC-076 - A Randomized Clinical Trial of Infrared Coagulation (IRC) Ablation versus Expectant Management of Intra-Anal High Grade Intraepithelial Neoplasia (HGAIN) in HIV-infected Subjects | NCT01164722 | Closed to accrual |
| AMC-072 - Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex with Males | NCT01209325 | Closed to accrual |
| AMC-081 - Feasibility Study of Safety, Toxicity, and Compliance of Concomitant Chemoradiotherapy for HIV-Associated Locally-Advanced Cervical Cancer | NCT01590017 | Closed to accrual |
| AMC-084 - Screening HIV-Infected Women for Anal Cancer Precursors | NCT01946139 | Closed to accrual |
| AMC-058 - A Companion Protocol To Evaluate Anogenital Human Papillomavirus (HPV) Infection And Anogenital Squamous Intraepithelial Lesions (ASIL) In Patients Participating In AMC Clinical Trials | NCT00695422 | Closed to accrual |
| NCT Number | Status | |
|---|---|---|
| AMC-108 - Multicenter Phase II Study of Pomalidomide Monotherapy in Kaposi Sarcoma | NCT04577755 | Closed to accrual |
| AMC-107 - A Phase 2 Trial of Ixazomib for Kaposi Sarcoma | NCT04305691 | Actively enrolling |
| AMC-114 - A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings | NCT05411237 | In Development |
| AMC-116 - A Phase II Study of Propranolol for the Treatment of Kaposi Sarcoma in Children and Adults | NCT05797662 | In Development |
| AMC-118 - A Phase II Study of Nirogacestat in Patients with Kaposi Sarcoma | TBD | In Development |
| AMC-096 - A Phase II Study of sEphB4-HSA in Kaposi Sarcoma | NCT02799485 | Closed to accrual |
| AMC-098 - A Pilot Study of Nelfinavir for the Treatment of Kaposi Sarcoma | NCT03077451 | Closed to accrual |
| AMC-090 - A Phase I/Pharmacokinetic Study of Erlotinib for Advanced Non-Small Cell Lung Cancer in Persons with HIV Infection | NCT02134886 | Closed to accrual |
| AMC-089 - A Phase I/II Study of Gamma Secretase Inhibitor PF-03084014 in Patients with AIDS-Associated Kaposi's Sarcoma | NCT02137564 | Closed to accrual |
| AMC-098 - Nelfinavir for the Treatment of AIDS KS | NCT03077451 | Closed to accrual |
| AMC-S007 - Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa | NCT03596918 | Closed to accrual |
| AMC-050 - Pilot Study Of Viral Load And Transcription In Kaposi's Sarcoma Patients Treated With Liposomal Anthracyclines | NCT00427414 | Closed to accrual |
| AMC-074/A5278s - Pharmacology Substudies of A5263 and A5264 | Closed to accrual | |
| AMC-100 - Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa | NCT03601806 | Closed to accrual |
| AMC-070 - A Phase I/II Study of Lenalidomide in Patients with AIDS-Associated Kaposi’s Sarcoma | NCT01057121 | Closed to accrual |
| AMC-067/A5254 - A Randomized Comparison of Antiretroviral Therapy Alone or with Delayed Chemotherapy versus Antiretroviral Therapy with Immediate Adjunctive Chemotherapy for Treatment of Limited Stage AIDS-KS in Resource-Limited Settings | NCT01352117 | Closed to accrual |
| AMC-043 - A Phase I & II Trial of VEGF- Antisense Oligenucleotide (VEGF-AS) in Patients with HIV Related Kaposi's Sarcoma | Closed to accrual | |
| AMC-066/A5263 - A Randomized Comparison of Three Regimens of Chemotherapy with Compatible Antiretroviral Therapy for Treatment of Advanced AIDS-KS in Resource-Limited Settings | NCT01435018 | Closed to accrual |
| AMC-063 - Single-Arm, Dose-Finding Pilot Trial of Single-Agent Bortezomib in Patients with Relapsed/Refractory Aids-Associated Kaposi Sarcoma with Correlative Assessments of KSHV and HIV | NCT01016730 | Closed to accrual |
| NCT Number | Status | |
|---|---|---|
| AMC-115 - Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC | NCT05510908 | Closed to accrual |
| AMC-083 - Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of HIV-1 Associated Malignancies | NCT01567722 | Closed to accrual |
| NCT Number | Status | |
|---|---|---|
| AMC-111 - Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living with HIV: A Feasibility Study | NCT04949464 | Actively enrolling |
| AMC-104 - Feasibility Study of Ocular Surface Squamous Neoplasia (OSSN) Surgical Excision in People Living with HIV in Sub-Saharan Africa (SSA) | NCT04704648 | Actively enrolling |
| AMC-045 - Phase II Trial Of Combined Modality Therapy Plus Cetuximab in HIV-Associated Anal Carcinoma | NCT00324415 | Closed to accrual |
| AMC-106 - A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer | NCT00324415 | Closed to accrual |
| AMC-087 - Phase I Trial of Cabozantinib (XL184) for Advanced Solid Tumors in Persons with HIV Infection | NCT01822522 | Closed to accrual |
| AMC-095 - A Phase I Study of Ipilimumab and Nivolumab in Advanced HIV-Associated Solid Tumors, with Expansion Cohorts in HIV-Associated Solid Tumors and a Cohort of HIV-Associated Classical Hodgkin Lymphoma | NCT02408861 | Closed to accrual |
| AMC-110 - Risk Adapted Therapy for HIV-Associated Anal Cancer | NCT04929028 | Closed to accrual |
| AMC-078 - A Phase 1 Study of Vorinostat in Combination with Paclitaxel and Carboplatin in Solid Tumors (with Focus on Upper Aerodigestive Cancers) in Persons with HIV Infection | NCT01249443 | Closed to accrual |