Kaposi's Sarcoma Working Group

• AMC-114

  A Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings

• AMC-098

  Nelfinavir for the Treatment of AIDS KS

• AMC-090

  A Phase I/Pharmacokinetic Study of Erlotinib for Advanced Non-Small Cell Lung Cancer in Persons with HIV Infection

• AMC-089

  A Phase I/II Study of Gamma Secretase Inhibitor PF-03084014 in Patients with AIDS-Associated Kaposi's Sarcoma

• AMC-074/A5278s

  Pharmacology Substudies of A5263 and A5264

• AMC-070

  A Phase I/II Study of Lenalidomide in Patients with AIDS-Associated Kaposi’s Sarcoma

• AMC-067/A5254

  A Randomized Comparison of Antiretroviral Therapy Alone or with Delayed Chemotherapy versus Antiretroviral Therapy with Immediate Adjunctive Chemotherapy for Treatment of Limited Stage AIDS-KS in Resource-Limited Settings

• AMC-066/A5263

  A Randomized Comparison of Three Regimens of Chemotherapy with Compatible Antiretroviral Therapy for Treatment of Advanced AIDS-KS in Resource-Limited Settings

• AMC-063

  Single-Arm, Dose-Finding Pilot Trial of Single-Agent Bortezomib in Patients with Relapsed/Refractory Aids-Associated Kaposi Sarcoma with Correlative Assessments of KSHV and HIV

• AMC-050

  Pilot Study Of Viral Load And Transcription In Kaposi's Sarcoma Patients Treated With Liposomal Anthracyclines

• AMC-043

  A Phase I & II  Trial of  VEGF- Antisense Oligenucleotide (VEGF-AS)  in Patients with HIV Related Kaposi's Sarcoma

• AMC-116

  A Phase II Study of Propranolol for the Treatment of Kaposi Sarcoma in Children and Adults

• AMC-114

  A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings

• AMC-108

  Multicenter Phase II Study of Pomalidomide Monotherapy in Kaposi Sarcoma

• AMC-107

  A Phase 2 Trial of Ixazomib for Kaposi Sarcoma

• AMC-100

  Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa

• AMC-S007

  Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Infected Individuals with Kaposi Sarcoma (KS) in Sub-Saharan Africa

• AMC-098

  A Pilot Study of Nelfinavir for the Treatment of Kaposi Sarcoma

• AMC-096

  A Phase II Study of sEphB4-HSA in Kaposi Sarcoma

• AMC-S008

  Prospective Observational Study of Site-Specific Incident and Prevalent Cases of Cancer in People Living with HIV/AIDS- in Latin America

• AMC-S006

  Improving Participation in AMC Clinical Trials (IMPACTS)

Solid Tumor Working Group

• AMC-106

  A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer

• AMC-078

  A Phase 1 Study of Vorinostat in Combination with Paclitaxel and Carboplatin in Solid Tumors (with Focus on Upper Aerodigestive Cancers) in Persons with HIV Infection

• AMC-045

  Phase II Trial Of Combined Modality Therapy Plus Cetuximab in HIV-Associated Anal Carcinoma

• AMC-104

  Feasibility Study of Ocular Surface Squamous Neoplasia (OSSN) Surgical Excision in People Living with HIV in Sub-Saharan Africa (SSA)

• AMC-110

  Risk Adapted Therapy for HIV-Associated Anal Cancer

• AMC-111

  Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living with HIV: A Feasibility Study

• AMC-095

  A Phase I Study of Ipilimumab and Nivolumab in Advanced HIV-Associated Solid Tumors, with Expansion Cohorts in HIV-Associated Solid Tumors and a Cohort of HIV-Associated Classical Hodgkin Lymphoma

• AMC-087

  Phase I Trial of Cabozantinib (XL184) for Advanced Solid Tumors in Persons with HIV Infection

Hematologic Malignancy Working Group

• AMC-091

  Phase I and Pharmacokinetic Study of Ibrutinib in HIV-Infected Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma

• AMC-086/9177

  Phase II Study of Dose-Adjusted EPOCH+/- Rituximab in Adults with Untreated Burkitt Lymphoma, C-Myc Positive Diffuse Large B-Cell Lymphoma and Plasmablastic Lymphoma

• AMC-085

  A Phase 1/2 Study Examining AVD and Brentuximab Vedotin in Patients with HIV and Advanced Stage Hodgkin's Lymphoma

  A Phase 1/2 Study Examining AVD and Brentuximab Vedotin in Patients with HIV and Advanced Stage Hodgkin's Lymphoma

• AMC-080/BMT CTN 0903

  Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodysplastic Syndromes in HIV-Infected Individuals

• AMC-079

  Quantification of HIV-1 Reservoirs in HIV-Positive Persons Receiving Response-Adapted Therapy for Stage III-IV Hodgkin Lymphoma: A Companion Protocol to SWOG Protocol S0816 (AMC-073)

• AMC-075

  A Sequential Phase I/Randomized Phase II Trial of Vorinostat and Risk-Adapted Chemotherapy with Rituximab in HIV-Related B-cell Non-Hodgkin’s Lymphoma

• AMC-073

  Phase II Study of Response-Adapted Therapy Using Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy Comprising ABVD With Versus Without Combination Chemotherapy Comprising Standard or Escalated BEACOPP in Patients with Stage III-IV Hodgkin Lymphoma

• AMC-071

  High Dose Chemotherapy with Autologous Stem Cell Rescue for Aggressive B Cell Lymphoma and Hodgkin Lymphoma in HIV-infected Patients

• AMC-068

  Randomized, Phase II Trial of CHOP vs. Oral Chemotherapy with Concomitant Antiretroviral Therapy in Patients with HIV-associated Lymphoma in Sub-Saharan Africa

• AMC-053

  Safety And Efficacy Trial Of The Anti-Viral And Anti-Tumor Activity Of Velcade Combined With (R) ICE In Subjects With Relapsed/Refractory AIDS-Associated Lymphoma

• AMC-044

  Phase II Trial Of ESHAP (Etoposide, Methylprednisolone, Cytosine Arabinoside, And Cisplatin) Followed By Zevalin As Consolidation Therapy In Relapsed/Refractory AIDS-Related Lymphomas

• AMC-113

  Observational Cohort Study of People Living with HIV Treated with CD19-Directed CAR T Cell Therapy for B-Cell Lymphoid Malignancies

• AMC-112

  Axicabtagene Ciloleucel in Relapsed or Refractory HIV-Associated Aggressive B-Cell Non-Hodgkin Lymphoma

• AMC-109

  Administration of HIV-specific T cells to HIV+ Patients Receiving High Dose Chemotherapy Followed by Autologous Stem Cell Rescue -Auto-RESIST

• AMC-097

  A Phase I Study of Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-Selected CD34+ Cells

• AMC-101

  Phase I and Dose-Expansion Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas

• AMC-105

  A Multicenter, Open-label Feasibility Study of Daratumumab with Dose-Adjusted EPOCH in Newly Diagnosed Plasmablastic Lymphoma

• AMC-S004

  Clinical and Genomic Factors for Prognosis of Primary Effusion Lymphoma

Human Papillomavirus Working Group

• AMC-084

  Screening HIV-Infected Women for Anal Cancer Precursors

• AMC-081

  Feasibility Study of Safety, Toxicity, and Compliance of Concomitant Chemoradiotherapy for HIV-Associated Locally-Advanced Cervical Cancer

• AMC-076

  A Randomized Clinical Trial of Infrared Coagulation (IRC) Ablation versus Expectant Management of Intra-Anal High Grade Intraepithelial Neoplasia (HGAIN) in HIV-infected Subjects

• AMC-072

  Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex with Males

• AMC-058

  A Companion Protocol To Evaluate Anogenital Human Papillomavirus (HPV) Infection And Anogenital Squamous Intraepithelial Lesions (ASIL) In Patients Participating In AMC Clinical Trials

• AMC-102

  Phase IIB Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Paclitaxel and Carboplatin in HIV-Infected Women with Locally Advanced Cervical Cancer (LACC)

• AMC-094

  HPV-Related Neoplasia Among HIV-Seropositive Indian Men Who Have Sex with Men (MSM)

• AMC-093

  Incidence of HIV and Other STI Among Indian Men Who Have Sex with Men (MSM)

• AMC-099

  HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV (COVENANT)

• AMC-A01

  Anal Cancer/HSIL Outcomes Research (ANCHOR) Study

• AMC-103

  A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive Individuals

• AMC-092

  A multicenter observational and feasibility study of excision of superficially invasive squamous cell carcinoma (SISCCA) of the anal canal and perianus in HIV-infected persons

• AMC-088

  A Randomized Phase III Study of Intra-anal Imiquimod 2.5% vs. Topical 5-Fluorouracil 5% vs. Observation for the Treatment of High-grade Squamous Anal Intraepithelial Lesions (HSIL) in HIV-infected Men and Women

Laboratory Resources Committee

• AMC-115

  Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AIDS Malignancy Consortium

• AMC-S005

  Biospecimen Collection and Donation to the AIDS and Cancer Specimen Resource (ACSR): A Companion Protocol to AMC Trials

• AMC-083

  Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of HIV-1 Associated Malignancies